Alignments

We have currently 15 alignments in our library (for ATM, BRCA1, BRCA2, CHEK2, TP53, MLH1, MRE11, MSH2, MSH6, NBN, PALB2, PMS2, RAD50, RAD51 and XRCC2)

   - ATM for which the 9 following sequences were used:
   (Click here to see ATM alignment (last updated 2008/10/28))
* Homo sapiens
* Mus musculus (mouse)
* Sus scrofa (pig)
* Monodelphis domesticus (grey, short tailed opossum)
* Gallus gallus (chicken)
* Xenopus laevis (frog)
* Danio rerio (zebrafish)
* Branchiostoma floridae (lancelet)
* Strongylocentrotus purpuratus (purple sea urchin)
 

   - BRCA1 for which the 13 following sequences were used:
   (Click here to see BRCA1 alignment (last updated 2007/11/08))
* Homo sapiens
* Pan troglodytes (chimpanzee)
* Gorilla gorilla
* Pongo pygmaeus (orangutan)
* Macaca mulatta (monkey)
* Mus musculus (mouse)
* Canis lupus familiaris (dog)
* Bos taurus (cow)
* Monodelphis domesticus (grey, short tailed opossum)
* Gallus gallus (chicken)
* Xenopus laevis (frog)
* Tetraodon nigroviridis (pufferfish - green spotted)
* Strongylocentrotus purpuratus (purple sea urchin)
 

   - BRCA2 for which the 12 following sequences were used:
   (Click here to see BRCA2 alignment (last updated 2007/11/08))
* Homo sapiens
* Pan troglodytes (chimpanzee)
* Macaca mulatta (monkey)
* Rattus norvegicus (rat)
* Canis familiaris (dog)
* Canis lupus familiaris (dog)
* Bos taurus (cow)
* Monodelphis domesticus (grey, short tailed opossum)
* Gallus gallus (chicken)
* Xenopus laevis (frog)
* Tetraodon nigroviridis (pufferfish - green spotted)
* Fugu rubripes (Pufferfish - fugu)
* Strongylocentrotus purpuratus (purple sea urchin)
 

   - CHEK2 for which the 13 following sequences were used:
   (Click here to see CHEK2 alignment (last updated 2010/06/04))
* Homo sapiens
* Mus musculus (mouse)
* Canis familiaris (dog)
* Bos taurus (cow)
* Loxodonta africana (elephant)
* Monodelphis domesticus (grey, short tailed opossum)
* Ornithorhynchus anatinus (platypus)
* Gallus gallus (chicken)
* Xenopus laevis (frog)
* Danio rerio (zebrafish)
* Strongylocentrotus purpuratus (purple sea urchin)
* Ciona intestinalis (sea quirt - tunicate)
* Drosophila melanogaster (fruitfly)
 

   - TP53 for which the 9 following sequences were used :
   (Click here to see TP53 alignment (last updated 2006/02/27))
* Homo sapiens
* Macaca mulatta (monkey)
* Bos taurus (cow)
* Canis familiaris (dog)
* Mus musculus (mouse)
* Rattus norvegicus (rat)
* Gallus gallus (chicken)
* Xenopus laevis (frog)
* Brachydanio rerio (zebrafish).
 

   - MLH1 for which the 14 following sequences were used:
   (Click here to see MLH1 alignment in FASTA format or COLORED EXCEL format (last updated 2012/08/13))
* Homo sapiens
* Macaca mulatta (monkey)
* Mus musculus (mouse)
* Canis lupus familiaris (dog)
* Monodelphis domestica (gray short-tailed opossum - marsupialia)
* Gallus gallus (chicken - aves)
* Xenopus laevis (frog - amphibia)
* Danio rerio (zebrafish - teleostei)
* Petromyzon marinus (lamprey eel - agnatha)
* Ciona intestinalis (sea quirt - urochordata)
* Branchiostoma floridae (lancelet - cephalochordate)
* Strongylocentrotus purpuratus (purple sea urchin - echinodermata)
* Nematostella vectensis (starlet anemone - cnidaria)
* Trichoplax adhearens (placozoa)
 

   - MRE11 for which the 16 following sequences were used :
   (Click here to see MRE11 alignment in COLORED EXCEL format (last updated 2013/10/31))
* Homo sapiens
* Macaca mulatta (monkey)
* Callithrix jacchus (marmoset)
* Mus musculus (mouse)
* Sus scrofa (pig)
* Loxodonta africana (elephant)
* Dasypus novemcinctus (armadillo)
* Monodelphis domestica (gray short-tailed opossum - marsupialia)
* Ornithorhynchus anatinus (ornithorhynch)
* Gallus gallus (chicken - aves)
* Anolis carolinensis lizard)
* Xenopus tropicalis (frog - amphibia)
* Latimeria chalumnae (coelacanth)
* Fugu rubripes (pufferfish - fugu)
* Branchiostoma floridae (lancelet - cephalochordate)
* Strongylocentrotus purpuratus (purple sea urchin - echinodermata)
 

   - MSH2 for which the 14 following sequences were used:
   (Click here to see MSH2 alignment in FASTA format or COLORED EXCEL format (last updated 2012/08/13))
* Homo sapiens
* Cercopithecus aethiops (monkey)
* Mus musculus (mouse)
* Bos taurus (cow)
* Monodelphis domesticus (grey, short tailed opossum)
* Gallus gallus (chicken)
* Xenopus laevis (frog)
* Danio rerio (zebrafish)
* Petromyzon marinus (lamprey eel - agnatha)
* Ciona intestinalis (sea quirt - tunicate)
* Branchiostoma floridae (lancelet - cephalochordate)
* Strongylocentrotus purpuratus (purple sea urchin - echinodermata)
* Nematostella vectensis (starlet anemone - cnidaria)
* Trichoplax adhearens (placozoa)
 

   - MSH6 for which the 14 following sequences were used:
   (Click here to see MSH6 alignment in FASTA format or COLORED EXCEL format (last updated 2012/08/13))
* Homo sapiens
* Macaca mulatta (monkey)
* Mus musculus (mouse)
* Bos Taurus (cow - laurasiatheria)
* Monodelphis domestica (gray short-tailed opossum - marsupialia)
* Gallus gallus (chicken - aves)
* Xenopus laevis (frog - amphibia)
* Danio rerio (zebrafish - teleostei)
* Petromyzon marinus (lamprey eel - agnatha)
* Ciona intestinalis (sea quirt - urochordata)
* Branchiostoma floridae (lancelet - cephalochordate)
* Strongylocentrotus purpuratus (purple sea urchin - echinodermata)
* Nematostella vectensis (starlet anemone - cnidaria)
* Trichoplax adhearens (placozoa)
 

   - NBN for which the 16 following sequences were used :
   (Click here to see NBN alignment in COLORED EXCEL format (last updated 2013/10/31))
* Homo sapiens
* Macaca mulatta (monkey)
* Callithrix jacchus (marmoset)
* Mus musculus (mouse)
* Bos Taurus (cow - laurasiatheria)
* Loxodonta africana (elephant)
* Dasypus novemcinctus (armadillo)
* Monodelphis domestica (gray short-tailed opossum - marsupialia)
* Ornithorhynchus anatinus (ornithorhynch)
* Gallus gallus (chicken - aves)
* Anolis carolinensis lizard)
* Xenopus tropicalis/laevis (frog - amphibia)
* Latimeria chalumnae (coelacanth)
* Danio rerio (zebrafish - teleostei)
* Branchiostoma floridae (lancelet - cephalochordate)
* Strongylocentrotus purpuratus (purple sea urchin - echinodermata)
 

   - PALB2 for which the 10 following sequences were used :
   (Click here to see PALB2 alignment in COLORED EXCEL format (last updated 2014/09/18))
* Homo sapiens
* Pan troglodytes (chimpanzee)
* Mus musculus (mouse)
* Canis lupus familiaris (dog)
* Bos taurus (cow - laurasiatheria)
* Equus caballus (horse)
* Monodelphis domestica (gray short-tailed opossum - marsupialia)
* Gallus gallus (chicken - aves)
* Xenopus tropicalis/laevis (frog - amphibia)
* Danio rerio (zebrafish - teleostei)
 

   - PMS2 for which the 14 following sequences were used:
   (Click here to see PMS2 alignment in FASTA format or COLORED EXCEL format (last updated 2012/08/13))
* Homo sapiens
* Macaca mulatta (monkey)
* Mus musculus (mouse)
* Bos Taurus (cow - laurasiatheria)
* Monodelphis domestica (gray short-tailed opossum - marsupialia)
* Gallus gallus (chicken - aves)
* Xenopus tropicalis (frog - amphibia)
* Danio rerio (zebrafish - teleostei)
* Petromyzon marinus (lamprey eel - agnatha)
* Ciona intestinalis (sea quirt - urochordata)
* Branchiostoma floridae (lancelet - cephalochordate)
* Strongylocentrotus purpuratus (purple sea urchin - echinodermata)
* Nematostella vectensis (starlet anemone - cnidaria)
* Trichoplax adhearens (placozoa)
 

   - RAD50 for which the 16 following sequences were used :
   (Click here to see RAD50 alignment in COLORED EXCEL format(last updated 2013/10/31))
* Homo sapiens
* Macaca mulatta (monkey)
* Callithrix jacchus (marmoset)
* Mus musculus (mouse)
* Bos Taurus (cow - laurasiatheria)
* Loxodonta africana (elephant)
* Dasypus novemcinctus (armadillo)
* Monodelphis domestica (gray short-tailed opossum - marsupialia)
* Ornithorhynchus anatinus (ornithorhynch)
* Gallus gallus (chicken - aves)
* Anolis carolinensis lizard)
* Xenopus tropicalis/laevis (frog - amphibia)
* Latimeria chalumnae (coelacanth)
* Danio rerio (zebrafish - teleostei)
* Branchiostoma floridae (lancelet - cephalochordate)
* Strongylocentrotus purpuratus (purple sea urchin - echinodermata)
 

   - RAD51 for which the 15 following sequences were used:
   (Click here to see RAD51 alignment (last updated 2012/03/20))
* Homo sapiens - with Accession Nb: NP_002866_RAD51
* Mus musculus (mouse) - with Accession Nb: NP_035364_RAD51
* Rattus norvegicus (rat) - with Accession Nb: NP_001102674_RAD51
* Oryctolagus cuniculus (rabbit) - with Accession Nb: NP_001075493_RAD51
* Canis familiaris (dog) - with Accession Nb: NP_001003043_RAD51
* Bos taurus (cow) - with Accession Nb: NP_001039644_RAD51
* Sus scrofa (pig) - with Accession Nb: NP_001116653_RAD51
* Monodelphis domesticus (grey, short tailed opossum) - with Accession Nb: RAD51_XP_001370830
* Gallus gallus (chicken) - with Accession Nb: NP_990504_RAD51
* Xenopus laevis (frog) - with Accession Nb: RAD51_NP_001081236
* Danio rerio (zebrafish) - with Accession Nb: NP_998371_cor_RAD51
* Branchiostoma floridae (lancelet) - with Accession Nb: cDNA_pep
* Ciona intestinalis (sea quirt - tunicate) - with Accession Nb: RAD51_XP_002126934
* Strongylocentrotus purpuratus (purple sea urchin) - with Accession Nb: RAD51_XP_788683
* Drosophila melanogaster (fruitfly) - with Accession Nb: RAD51_NP_524583
 

   - XRCC2 for which the 15 following sequences were used:
   (Click here to see XRCC2 alignment (last updated 2011/10/03))
* Homo sapiens
* Macaca mulatta (monkey)
* Mus musculus (mouse)
* Canis familiaris (dog)
* Loxodonta africana (elephant)
* Monodelphis domesticus (grey, short tailed opossum)
* Ornithorhynchus anatinus (ornithorhynch)
* Gallus gallus (chicken)
* Anolis carolinensis (lizard)
* Xenopus tropicalis
* Danio rerio (zebrafish)
* Branchiostoma floridae (lancelet)
* Strongylocentrotus purpuratus (purple sea urchin)
* Nematostella vectensis (starlet anemone)
* Trichoplax adhaerens (trichoplax)
 


   Click here to see BRCA1 and BRCA2 TSMR demonstration

18/09/2014